hummingbot/hummingbot
Open‑source framework for building and deploying algorithmic crypto‑trading bots; includes CLI, Docker, many exchange connectors, and optional LLM‑driven decision layer (Condor).
ammaarreshi/RedAlert2-Mac-iOS-iPad
A native-feeling port of Command & Conquer: Red Alert 2 and Yuri's Revenge for iOS and iPadOS, featuring custom RTS touch controls and a rebuilt skirmish AI.
codedeliveryservice/Reckless
Reckless is a high-performance, open-source competitive chess engine that ranks among the top engines in major tournaments like CCC and TCEC.
NomaDamas/slides-grab
slides-grab is a CLI tool for creating and editing HTML slides with AI agent assistance. It provides a visual editor, exports to PDF/PNG/PPTX, includes design templates, and can generate images via AI. It's designed to be used by coding agents like Claude or Codex, making it a practical application of AI in presentation workflows.
PennyLaneAI/pennylane
PennyLane is an open-source software platform designed for quantum computing, quantum machine learning, and quantum chemistry, enabling users to build and implement quantum algorithms across various hardware devices.
microsoft/mattergen
MatterGen is a generative diffusion model for inorganic materials design that can be fine-tuned to generate crystal structures based on specific property constraints.
pmariglia/foul-play
A Pokemon Showdown battle-bot that uses a search engine to play single battles across multiple generations of the game.
RosettaCommons/foundry
A tooling and infrastructure framework for protein design, providing a unified interface for generative models like RFdiffusion3 and structure prediction models like RosettaFold3.
bupticybee/TexasSolver
An efficient C++ solver for Texas Hold'em and short deck poker that calculates optimal game strategies.
openmm/openmm
OpenMM is a high-performance molecular dynamics library for molecular simulation, offering extreme flexibility and GPU optimization for researchers.
Classiq/classiq-library
An end-to-end platform for designing, optimizing, and executing quantum software that transforms high-level functional logic into optimized quantum circuits.
thomas-mauran/chess-tui
A cross-platform terminal chess game written in Rust that supports local play, UCI chess engines like Stockfish, and Lichess integration.
sokrypton/ColabDesign
A collection of Google Colab notebooks that make protein design accessible by integrating tools like AlphaFold, ProteinMPNN, and Rfdiffusion.
rooklift/nibbler
A real-time analysis GUI for Leela Chess Zero (Lc0) that provides graphical visualizations of engine evaluations and move choices.
dptech-corp/Uni-Dock
A GPU-accelerated molecular docking program that enables ultralarge virtual screening by providing massive speed-ups over CPU-based tools.
jcmgray/quimb
A Python library for quantum information many-body calculations focusing on tensor networks and exact matrix-based simulations.
qiskit-community/qiskit-nature
An open-source framework for solving quantum mechanical natural science problems, such as molecular electronic structures and lattice models, using quantum computing algorithms.
quantumlib/OpenFermion
A Python package for compiling and analyzing quantum algorithms to simulate fermionic systems and quantum chemistry on quantum computers.
NetLogo/NetLogo
NetLogo is a programmable modeling environment for creating agent-based simulations to study complex systems and emergent behavior.
quantumlib/Cirq
A Python package for writing, manipulating, and running quantum circuits on quantum computers and simulators, optimized for NISQ-era hardware.
NVIDIA/cuda-quantum
A platform for hybrid quantum-classical computing that integrates QPUs, GPUs, and CPUs into a single programmable system.
BIMK/PlatEMO
PlatEMO is a MATLAB platform for evolutionary multi-objective optimization, offering 300+ algorithms and 600+ benchmark problems with a user-friendly GUI and parallel experiment support. It helps researchers test and compare optimization methods easily.
ccsb-scripps/AutoDock-Vina
AutoDock Vina is an open-source docking engine used for molecular docking and virtual screening to predict how ligands bind to proteins.
MolecularAI/REINVENT4
A molecular design tool that uses reinforcement learning and transfer learning to generate optimized small molecules based on user-defined property profiles.
zxcalc/pyzx
A Python tool for the creation, visualization, and automated simplification of large-scale quantum circuits using the ZX-calculus diagrammatic reasoning system.
glotzerlab/hoomd-blue
A Python package for high-performance particle simulations on CPUs and GPUs, supporting hard particle Monte Carlo and molecular dynamics.
aibasel/downward
Fast Downward is a domain-independent classical planning system used to solve general-purpose planning tasks for scientific research.
dwavesystems/dwave-ocean-sdk
A suite of tools for solving computationally hard problems using D-Wave quantum computers via the Leap cloud service.
team-ocean/veros
A high-performance ocean simulator written in pure Python that supports JAX for GPU acceleration and MPI for distributed computing to model everything from toy models to global oceans.
lightdock/lightdock
A docking framework based on the Glowworm Swarm Optimization algorithm for predicting interactions between proteins, peptides, and DNA.
tqec/tqec
A design automation tool for representing and compiling large-scale fault-tolerant quantum computations based on surface code and lattice surgery.
springfall2008/batpred
A home battery prediction and automatic charging system for Home Assistant that supports multiple inverter brands to optimize energy storage.
gempy-project/gempy
An open-source Python library for 3D geological modeling that uses implicit representations to construct complex folded structures, fault networks, and unconformities.
jensengroup/propka
A tool for predicting pKa values of ionizable groups in proteins and protein-ligand complexes based on their 3D structure.
apistol78/traktor
A high-performance open-source 3D game engine written in C++ featuring advanced Vulkan rendering, hardware ray tracing, and built-in AI integration via an MCP server.
yashlamba/handwrite
Handwrite is a tool that generates a custom font based on a user's handwriting sample, allowing them to type documents that look handwritten.
Mugen87/yuka
A JavaScript library for developing Game AI, providing tools for autonomous agent design, steering, navigation, and fuzzy logic.
RosettaCommons/rosetta
A biomolecular modeling library used for the computational analysis and design of protein structures, enzymes, and biological macromolecules.
aiplan4eu/unified-planning
A Python library for modeling and solving automated planning problems in a planner-independent way, supporting various solvers and PDDL formats.
QuantumBFS/Yao.jl
An extensible Julia framework for quantum algorithm design and simulation, designed for research, education, and quantum software development.
yhyu13/AlphaGOZero-python-tensorflow
A Python and TensorFlow implementation of AlphaGo Zero that allows an AI to learn to play the game of Go through self-play and reinforcement learning.
xqbase/eleeye
An open-source XiangQi (Chinese Chess) engine that uses Alpha-Beta search and bitboard move generation to provide strong AI gameplay.
Quantinuum/tket
A high-performance quantum compiler that optimizes quantum circuits for a wide range of quantum computing architectures.
neuronsimulator/nrn
NEURON is a simulator for models of individual neurons and networks of neurons, providing a research-grade environment for biological neural simulation.
softwareQinc/qpp
A modern C++ general-purpose quantum computing library for simulating arbitrary quantum processes with high performance and low dependencies.
amazon-braket/amazon-braket-sdk-python
A Python SDK that provides a framework for interacting with quantum computing hardware and simulators through Amazon Braket.
GregoryCannon/StackRabbit
An AI that plays NES Tetris at a high level using search, heuristics, and value iteration, featuring clients for both emulators and real hardware.
AllenInstitute/bmtk
The Brain Modeling Toolkit (BMTK) is an open-source software suite for building, simulating, and analyzing large-scale brain networks across multiple levels of resolution.