3dem/relion

Image-processing software for cryo-electron microscopy

What it solves

RELION provides a way to refine 3D reconstructions or 2D class averages from cryo-electron microscopy data, helping researchers achieve high-resolution structural biology research.

How it works

It uses a Maximum A Posteriori (MAP) refinement approach, specifically Regularised Likelihood Optimisation, to process microscopy images and reconstruct the 3D structures of biological molecules.

Who it’s for

Structural biologists and researchers using cryo-electron microscopy (cryo-EM) to determine the 3D shapes of biological molecules.

Highlights

  • Stand-alone computer program for high-resolution 3D reconstruction.
  • Supports both 3D reconstructions and 2D class averages.
  • Integrates with Python modules like Blush, ModelAngelo, and DynaMight.
  • Includes a class ranker model based on PyTorch and NumPy.

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